Students learn about the form and function of the human heart through the dissection of sheep hearts. They learn about the different parts of the heart and are able to identify the anatomical structures and compare them to the all of the structural components of the human heart they learned about in the associated lesson, Heart to Heart.

Students learn about the separation techniques of sedimentation and centrifugation and investigate whether blood is a homogeneous or a heterogeneous mixture. Working in groups as if they are biomedical researchers, they employ the scientific method and make observations about the known characteristics of urine, milk and blood. They probe further by analyzing research on the properties and fractionation modes of blood. As students learn about certain strange characteristics with the fractionation behavior of blood, they formulate hypotheses on the unique nature of blood. Using provided materials —olive oil, tomato juice and petroleum jelly—they design an experiment and construct a blood model. They test their hypotheses by conducting experiments on the blood model, and then propose theories for the nature of blood as a mixture—arriving at the theory of mixture dualism in blood—that blood is a complex mixture system. An activity-guiding handout and PowerPoint® presentation are provided for this student-directed, project-based activity.

Students learn about the advantages and disadvantages of the greenhouse effect. They construct their own miniature greenhouses and explore how their designs take advantage of heat transfer processes to create controlled environments. They record and graph measurements, comparing the greenhouse indoor and outdoor temperatures over time. Students are also introduced to global issues such as greenhouse gas emissions and their relationship to global warming.

Students use provided materials to design and build prototype artificial heart valves. Their functioning is demonstrated using water to simulate the flow of blood through the heart. Upon completion, teams demonstrate their fully functional prototypes to the rest of the class, along with a pamphlet that describes the device and how it works.

Students are challenged to use computer-aided design (CAD) software to create “complete” 3D-printed molecule models that take into consideration bond angles and lone-pair positioning. To begin, they explore two interactive digital simulations: “build a molecule” and “molecule shapes.” This aids them in comparing and contrasting existing molecular modeling approaches—ball-and-stick, space-filling, and valence shell electron pair repulsion (VSEPR)—so as to understand their benefits and limitations. In order to complete a worksheet that requires them to draw Lewis dot structures, they determine the characteristics and geometries (valence electrons, polar bonds, shape type, bond angles and overall polarity) of 12 molecules. They also use molecular model kits. These explorations and exercises prepare them to design and 3D print their own models to most accurately depict molecules. Pre/Post quizzes, a step-by-step Blender 3D software tutorial handout and a worksheet are provided.

Students work as engineers to learn about the properties of molecules and how they move in 3D space through the use of LEGO MINDSTORMS(TM) NXT robotics. They design and build molecular models and use different robotic sensors to control the movement of the molecular simulations. Students learn about the size of atoms, Newman projections, and the relationship of energy and strain on atoms. This unique modular modeling activity is especially helpful in providing students with a spatial and tactile understanding of how molecules behave.

Students learn the physical properties of sound, how it travels and how noise impacts human health—including the quality of student learning. They learn different techniques that engineers use in industry to monitor noise level exposure and then put their knowledge to work by using a smart phone noise meter app to measure the noise level at an area of interest, such as busy roadways near the school. They devise an experimental procedure to measure sound levels in their classroom, at the source of loud noise (such as a busy road or construction site), and in between. Teams collect data using smart phones/tablets, microphones and noise apps. They calculate wave properties, including frequency, wavelength and amplitude. A PowerPoint® presentation, three worksheets and a quiz are provided.

Students design, build and evaluate a spring-powered mouse trap racer. For evaluation, teams equip their racers with an intelligent brick from a LEGO© MINDSTORMS© NXT Education Base Set and a HiTechnic© acceleration sensor. They use acceleration data collected during the launch to compute velocity and displacement vs. time graphs. In the process, students learn about the importance of fitting mathematical models to measurements of physical quantities, reinforce their knowledge of Newtonian mechanics, deal with design compromises, learn about data acquisition and logging, and carry out collaborative assessment of results from all participating teams.

Students are introduced to the futuristic concept of the moon as a place people can inhabit. They brainstorm what people would need to live on the moon and then design a fantastic Moon colony and decide how to power it. Students use the engineering design process, which includes researching various types of energy sources and evaluating which would be best for their moon colonies.

Given an assortment of unknown metals to identify, student pairs consider what unique intrinsic (aka intensive) metal properties (such as density, viscosity, boiling or melting point) could be tested. For the provided activity materials (copper, aluminum, zinc, iron or brass), density is the only property that can be measured so groups experimentally determine the density of the "mystery" metal objects. They devise an experimental procedure to measure mass and volume in order to calculate density. They calculate average density of all the pieces (also via the graphing method if computer tools area available). Then students analyze their own data compared to class data and perform error analysis. Through this inquiry-based activity, students design their own experiments, thus experiencing scientific investigation and experimentation first hand. A provided PowerPoint(TM) file and information sheet helps to introduce the five metals, including information on their history, properties and uses.

Through two lessons and four activities, students learn about nanotechnology, its extreme smallness, and its vast and growing applications in our world. Embedded within the unit is a broader introduction to the field of material science and engineering and its vital role in nanotechnology advancement. Engaging mini-lab activities on ferrofluids, quantum dots and gold nanoparticles introduce students to specific fields within nanoscience and help them understand key concepts as the basis for thinking about engineering and everyday applications that use next-generation technology nanotechnology.

Student teams learn how water filtration systems that use nanoparticles and nanotechnology can remove organic compounds from water. First they learn about the role nanoparticles play in water filtration. Then they are introduced to the basics of nanoparticles and nanotechnology, focusing on the impacts and benefits this innovative technology has on our daily lives. Using methylene blue and methyl orange solutions, students test for the efficiency of photocatalytic nanoparticles to sanitize water. They expose a solution sample of water and methyl orange (the microbe indicator) with their newly-made water sanitation filters under UV light (sunlight) to activate the photocatalytic properties of three specific nanoparticles. They visually compare them with control samples to determine the best photocatalytic nanoparticle to sanitize water.

Students apply the knowledge gained from the previous lessons and activities in this unit to write draft grant proposals to the U.S. National Institutes of Health outlining their ideas for proposed research using nanoparticles to protect against, detect or treat skin cancer. Through this exercise, students demonstrate their understanding of the environmental factors that contribute to skin cancer, the science and mathematics of UV radiation, the anatomy of human skin, current medical technology applications of nanotechnology and the societal importance of funding research in this area, as well as their communication skills in presenting plans for specific nanoscale research they would conduct using nanoparticles.

Through a scavenger hunt, students are introduced to the world of nanotechnology. In the form of a competition, groups race to locate symbols that correlate to an answer to a general nanotechnology question. Each team receives paper slips with questions; the remaining questions are hidden behind QR codes. Groups need to answer eight total questions in the correct order. Because this is an intro to nanotechnology and its associated engineering, students need to use problem-solving skills in order to identify the correct answers. After the initial scavenger hunt, a brief class discussion explores advances in nanotechnology. Next, students work in teams to research different areas of nanotechnology as they create their own scavenger hunt games.

Students learn about the biomedical use of nanoparticles in the detection and treatment of cancer, including the use of quantum dots and lasers that heat-activate nanoparticles. They also learn about electrophoresis a laboratory procedure that uses an electric field to move tiny particles through a channel in order to separate them by size. They complete an online virtual mini-lab, with accompanying worksheet, to better understand gel electrophoresis. This prepares them for the associated activity to write draft research proposals to use nanoparticles to protect against, detect or treat skin cancer.

Students are given a general overview of nanotechnology principles and applications, as well as nanomaterials engineering. Beginning with an introductory presentation, they learn about the nano-scale concept and a framework for the length scales involved in nanotechnology. Engineering applications are introduced and discussed. This prepares students to conduct the associated activity in which they relate the nano-length scale to everyday objects. At completion, students are able to identify nanotechnology applications and have a frame of reference for the second lesson of the unit.

In this activity, students explore the importance of charts to navigation on bodies of water. Using one worksheet, students learn to read the major map features found on a real nautical chart. Using another worksheet, students draw their own nautical chart using the symbols and identifying information learned.

For thousands of years, navigators have looked to the sky for direction. Today, celestial navigation has simply switched from using natural objects to human-created satellites. A constellation of satellites, called the Global Positioning System, and hand-held receivers allow for very accurate navigation. In this lesson, students investigate the fundamental concepts of GPS technology trilateration and using the speed of light to calculate distances.

In this lesson, students will learn that math is important in navigation and engineering. Ancient land and sea navigators started with the most basic of navigation equations (Speed x Time = Distance). Today, navigational satellites use equations that take into account the relative effects of space and time. However, even these high-tech wonders cannot be built without pure and simple math concepts basic geometry and trigonometry that have been used for thousands of years. In this lesson, these basic concepts are discussed and illustrated in the associated activities.

Students examine how the orientation of a photovoltaic (PV) panel relative to the sun affects the efficiency of the panel. Using sunshine (or a lamp) and a small PV panel connected to a digital multimeter, students vary the angle of the solar panel, record the resulting current output on a worksheet, and plot their experimental results.