Students are presented with information that will allow them to recognize that yeasts are unicellular organisms that are useful to humans. In fact, their usefulness is derived from the contrast between the way yeast cells and human cells respire. Specifically, while animal cells derive energy from the combination of oxygen and glucose and produce water and carbon dioxide as by-products, yeasts respire without oxygen. Instead, yeasts break glucose down and produce alcohol and carbon dioxide as their by-products. The lesson is also intended to provoke questions from students about the effects of alcohol on the human body, to which the teacher can provide objective answers.

Students are presented with the unit's grand challenge problem: You are the lead engineer for a biomaterials company that has a cardiovascular systems client who wants you to develop a model that can be used to test the properties of heart valves without using real specimens. How might you go about accomplishing this task? What information do you need to create an accurate model? How could your materials be tested? Students brainstorm as a class, then learn some basic information relevant to the problem (by reading the transcript of an interview with a biomedical engineer), and then learn more specific information on how heart tissues work their structure and composition (lecture information presented by the teacher). This prepares them for the associated activity, during which students cement their understanding of the heart and its function by dissecting sheep hearts to explore heart anatomy.

Students are introduced to the concept of refraction. After making sure they understand the concepts of diffraction and interference, students work collaboratively to explain optical phenomena that cannot be accounted for via these two mechanisms alone. Then, through the associated activity, students see first-hand how refraction can work with interference to produce color patterns, similar to how nanosensors work. Finally, students apply their knowledge of refraction to the original challenge question to generate a possible solution in the form of a biosensor.

Students use modeling clay, a material that is denser than water and thus ordinarily sinks in water, to discover the principle of buoyancy. They begin by designing and building boats out of clay that will float in water, and then refine their designs so that their boats will carry as great a load (metal washers) as possible. Building a clay boat to hold as much weight as possible is an engineering design problem. Next, they compare amount of water displaced by a lump of clay that sinks to the amount of water displaced by the same lump of clay when it is shaped so as to float. Determining the masses of the displaced water allows them to arrive at Archimedes' principle, whereby the mass of the displaced water equals the mass of the floating clay boat.

Geographic information systems (GIS) are important technology that allows rapid study and use of spatial information. GIS have become increasingly prevalent in industry and the consumer/internet world in the last 20 years. Historically, the basis of GIS was in mapping, and so it is important to understand the basis of maps and how to use them as well as why they are different from GIS. In this lesson, students learn the value of maps, how to use maps, and the basic components of a GIS. They are also introduced to numerous GIS applications.

Students begin to explore the idea of a force. To further their understanding of drag, gravity and weight, they conduct activities that model the behavior of parachutes and helicopters. An associated literacy activity engages the class to recreate the Wright brothers' first flight in the style of the "You Are There" television series.

As a part of the research and revise step of the Legacy Cycle, this lesson provides students with information they will need later on to be able to average pixels to simulate blurring in the peripheral plane of vision. Students learn why image color becomes important as we distort the outer boundaries of an image and have to interpolate pixels to fill in gaps created from our algorithm. Students learn what a digital image is, what pixels are, and how to convert between RGB and hexadecimal values.

Students learn about friction and drag two different forces that convert energy of motion to heat. Both forces can act on a moving object and decrease its velocity. Students learn examples of friction and drag, and suggest ways to reduce the impact of these forces. The equation that governs common frictional forces is introduced, and during a hands-on activity, students experimentally measure a coefficient of friction.

In this lesson, students are shown the very basics of navigation. The concepts of relative and absolute location, latitude, longitude and cardinal directions are discussed, as well as the use and principles of a map and compass.

Investigating a waterwheel illustrates to students the physical properties of energy. They learn that the concept of work, force acting over a distance, differs from power, which is defined as force acting over a distance over some period of time. Students create a model waterwheel and use it to calculate the amount of power produced and work done.

Students set up a simple way to indirectly observe and quantify the amount of respiration occurring in yeast-molasses cultures. Each student adds a small amount of baking yeast to a test tube filled with diluted molasses. A second, smaller test tube is then placed upside-down inside the solution. As the yeast cells respire, the carbon dioxide they produce is trapped inside the inverted test tube, producing a growing bubble of gas that is easily observed and measured. Students are presented with the procedure for designing an effective experiment; they learn to think critically about experimental results and indirect observations of experimental events.