The aim of this presentation is to address different hot topics in our current understanding of aetiology as well as of the pathophysiology of Type 2 Diabetes. We’ll address how genetic as well as epi-genetic and non-genetic mechanisms may be involved in the complex mechanisms underlying type 2 diabetes. We’ll also introduce recent data suggesting that immature stem-cell functions are likely to play an important role for development of type 2 diabetes and its associated cardiometabolic disturbances. Finally we’ll address the current treatment options of disease with respect of both pharmacological and non-pharmacological treatment modalities.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

This presentation address the multifactorial etiology of type 2 diabetes. The multifactorial etiology, can be divided into three major categories, primary predisposing factors, secondary precipitating factors, as well as tertiary accelerating factors.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

The aim of this presentation is to address and understand the paradigm shifting consequences of the Thrifty Phenotype Hypothesis as a conceptual framework to understand the roots of type 2 diabetes.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

During the last couple of decades two new remarkably successful principles for diabetes therapy have appeared and are now used worldwide. These are incretin based therapy and surgical therapy. These two are at some extent linked together and in this lecture we’ll provide an introduction to these two principles for diabetes therapy.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

In this presentation we’ll talk about the effects of GLP-1 (Glucagon Like Peptide 1), GLP-1 has important actions on gastrointestinal secretion and motility, and it acts to inhibit appetite and food intake. In continuation of the effects of GLP-1, we’ll talk about GLP-1, GIP, lipids, proteins, and dipeptidyl peptidase-4.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

This presentation talks about intravenously GLP-1 infusion to patients with type 2 diabetes. The GLP-1 infusion is capable of restoring fasting glucose concentrations during the night time and can nearly normalize the meal-induced glucose excursions after meal ingestion. GLP-1 has many attractive actions regarding diabetes type 2 treatment, which is the theme of this presentation.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

This presentation provides an introduction to some of the basic aspects of the epidemiology of diabetes. In continuation of this we’ll discuss why diabetes is such a serious disease and what the biological mechanics of the disease are.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

This presentation will look at how the distribution of diabetes is, thus we’ll discuss how the distribution of diabetes are by type, gender, age, geographical region and ethnicity. The purpose of this discussion is to understand how serious a health problem the global epidemic of diabetes is, while increasing the understanding that it’s extremely necessary that we do whatever we can to fight against the diabetes epidemic in the future.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

This presentation tries to identify the most important risk factors for developing diabetes. In order to take the next steps in planning diabetes prevention, we need to know what distinguished those at risk of developing diabetes from those who aren’t or are at lower risk within the populations.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

This presentation provides an introduction to the genetic aspects of non-autoimmune diabetes. First we’ll introduce the genetic basis of diabetes, then we’ll talk about methods to identify genetic loci associated with diabetes and pre-diabetic traits. In continuation of this, we’ll provide examples of monogenic forms of diabetes and finally we’ll discuss common forms of non-autoimmune diabetes.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

This presentation provides an introduction to methods used to identify genetic loci affecting diabetes and pre-diabetes traits. Furthermore we’ll discuss aspects that are important when choosing and considering different methods.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

In this presentation we’ll present a genetic atlas of the non-autoimmune diabetes and describe monogenic forms of diabetes.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

This presentation provides an introduction to the genetics behind the common forms of type 2 diabetes. Furthermore we’ll provide an introduction to the Genome-Wide Association Study, this study is a hypothesis generating method that contains a discovery and a replication sample.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

This presentations discuss diabetes as an disease of the pancreatic beta cell, in continuation of this, we’ll discuss what causes beta cell failure in type 1 and type 2 diabetes. Furthermore we’ll discuss the innate immune system and the beta cell failure, and inflammatory mediators as therapeutic targets of type 1 and type 2 diabetes.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

This presentation provides an introduction to the immune system and how it’s activated. In continuation of this we’ll discuss how inflammatory beta cell destruction comes about in type 1 diabetes. Furthermore we’ll discuss how beta cell failure occur in type 2 diabetes.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

In this interview with Dr. Robert Ross we discuss what a successful obesity management is and what a clinical meaningful weight loss is? Furthermore we discuss recommendations regarding physical activity for health in the general population and which strategies we should take to have people sustain physical activity in the long run.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

The aim of this lecture is to give the student a new perspective on the muscle, the largest organ in the body. Skeletal muscles are primary identified by the mechanical activity required for posture, movement and breathing, which depends on muscle fiber contractions. However skeletal muscle isn’t just a component in our locomotor system.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

This presentation focuses on the current and novel approaches used to develop drugs in the treatment of obesity. We’ll introduce the student to the physiological regulation of appetite and satiety in relation to meals, then we’ll provide an short overview of the previous and current treatment on the market for the treatment of obesity and finally we’ll describe some of the promising novel approaches pursued for future treatment.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

This presentation provides an overview of the existing treatment available for treatment of obesity. Genetic studies have revealed that the genes contributing to development of obesity is mainly located in the brain, therefore it would be logical to tro to target the brain when pursuing drugs for the treatment of obesity. However it’s not that simple.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst

This presentation focus’ on the health benefits of being physically active and describes how physical training affects energy balance and metabolic health. Furthermore we’ll discuss the potential of physical training in prevention and treatment of obesity and diabetes and finally we’ll demonstrate methods that can be used to evaluate physical fitness, body fat distribution and insulin sensitivity.

Course responsible: Associate Professor Signe Sørensen Torekov, MD Nicolai Wewer Albrechtsen & Professor Jens Juul Holst